Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism

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Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.

Point mutations at Arg132 of the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase 1 (IDH1) occur frequently in gliomas and result in a gain of function to produce the "oncometabolite" D-2-hydroxyglutarate (D-2HG). The mutated IDH1 allele is usually associated with a wild-type IDH1 allele (heterozygous) in cancer. Here, we identify 2 gliomas that underwent loss of the wild-type IDH1 allele...

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Mutant IDH1 is required for IDH1 mutated tumor cell growth

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2020

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1913633117